FYI April 08, 2018


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On This Day

1906 – Auguste Deter, the first person to be diagnosed with Alzheimer’s disease, dies.

Auguste Deter (German pronunciation: [aʊ̯ˈɡʊstə ˈdeːtɐ]; 16 May 1850 – 8 April 1906) was a German woman notable for being the first person to be diagnosed with Alzheimer’s disease. Her maiden name is unknown. She married Karl Deter in the 1880s and together they had one daughter. During the late 1890s, she started showing symptoms of dementia, such as loss of memory, delusions, and even temporary vegetative states. She would have trouble sleeping, drag sheets across the house, and scream for hours in the middle of the night.

As a railway worker, Karl was unable to provide adequate care for his wife. He had her admitted to a mental institution, the Institution for the Mentally Ill and for Epileptics (Irrenschloss) in Frankfurt, Germany on 25 November 1901. There, she was examined by Dr. Alois Alzheimer.

Dr. Alzheimer asked her many questions, and later asked again to see if she remembered. He told her to write her name. She tried to, but would forget the rest and repeat: “I have lost myself.” (German: “Ich hab mich verloren.”) He later put her in an isolation room for a while. When he released her, she would run out screaming, “I will not be cut. I do not cut myself.” [1]

After many years, she became completely demented, muttering to herself. She died on 8 April 1906. More than a century later, her case was re-examined with modern medical technologies, where a genetic cause was found for her disease by scientists from Gießen and Sydney. The results were published in the journal The Lancet Neurology. According to this paper, a mutation in the PSEN1 gene was found, which alters the function of gamma secretase, and is a known cause of early-onset Alzheimer’s disease.[2] However, the results could not be replicated in a more recent paper published in 2014 where “Auguste D’s DNA revealed no indication of a nonsynonymous hetero- or homozygous mutation in the exons of APP, PSEN1, and PSEN2 genes comprising the already known familial AD mutations.” [3]



Born On This Day

1886 – Margaret Ayer Barnes, American author and playwright (d. 1967)
Margaret Ayer Barnes (April 8, 1886, Chicago, Illinois – October 25, 1967, Cambridge, Massachusetts) was an American playwright, novelist, and short-story writer.

She attended Bryn Mawr College, where she earned an A.B. degree in 1907. In 1936, she received an honorary degree in Doctor of Letters from Oglethorpe University. She married Cecil Barnes in 1910, and had three sons, Cecil Jr., Edward Larrabee and Benjamin Ayer. In 1920, Barnes was elected alumnae director of Bryn Mawr and served three years. As director, she helped to organize the Bryn Mawr Summer School for Women Workers in Industry, which offered an alternative educational program for women workers within a traditional institution. Consisting mainly of young, single immigrant women with little to no academic background, the summer program offered courses in progressive education, liberal arts and economics. Women in the program were encouraged to develop confidence as speakers, writers and leaders in the workplace.[1]

In 1926, at age 40, she broke her back in a traffic accident, and, with the encouragement of friend and playwright Edward Sheldon, took up writing as a way to occupy her time. Between 1926 and 1930 she wrote several short stories and three plays, including an adaptation of Edith Wharton’s novel The Age of Innocence. In 1931 she won the Pulitzer Prize for her first novel, Years of Grace.

A 1936 lawsuit against Metro-Goldwyn-Mayer for copyright infringement claimed that the script MGM used for the motion picture Letty Lynton (1932) plagiarized material from the play Dishonored Lady by Edward Sheldon and Barnes.[2] The film is still unavailable today because of this lawsuit.

Personal life

Barnes was the wife of a prominent Chicago attorney. Her older sister was suffragette and fellow author Janet Ayer Fairbank (1878–1951), and her niece Janet Fairbank (1903–1947) was a well-known operatic singer. Her son was the noted architect Edward Larrabee Barnes (1915-2004).[3]

The Age of Innocence, a dramatization of Edith Wharton’s novel of the same name (produced 1928), made into a 1934 motion picture of the same name.
Jenny, a play, with Edward Sheldon (1929).
Dishonored Lady, a play, also with Sheldon (1930), made into a 1947 motion picture of the same name (aka Sins of Madeleine) starring Hedy Lamarr and released by United Artists.
Prevailing Winds, short stories (1928).
Years of Grace, a novel (1930), for which she was awarded the Pulitzer Prize.
Westward Passage, a novel (1931), made into a 1932 motion picture of the same name.
Within This Present, a novel (1933).
Edna, His Wife, a novel (1935), later adapted into a play of the same name by Cornelia Otis Skinner.
Wisdom’s Gate, a novel (1938).



By Elizabeth Werth: Driving Advice For Women In 1909: Don’t Forget To Bring A Gun

By Sam barsanti: Just in time for Rex Manning Day, an Empire Records musical is in the works
By Jake Rosen: The Enduring Mystery of the Oreo Cookie Design
Maria Popova’s Brain Pickings: Nietzsche on Truth, Lies, the Power and Peril of Metaphor, and How We Use Language to Reveal and Conceal Reality
By JOHN SKIPPER for the Globe Gazette: Dorothy Garlock, author who preferred Clear Lake to New York, dies
Valerie Hilal: Love life

I’m ALIVE — 
it seems like such a simple truth,
basically, a fact.
But, the breath I just exhaled
Can’t be taken back.
So, a reminder is in order
To me, myself, and I
that I cannot let the days slip past,
Can’t let them pass me by.
Mom got forty-three years;
I have had my share.
And though aging takes its toll,
it’s a cross I’ll gladly bear.
But, gratitude’s a fickle thing
As breezy as the wind,
So I remind myself today again…
This day,
will end.

But, hot damn, right now I’m Alive !

By Gfire: Anti-Nester™ – (Bird Nesting Deterent)



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By Jessica Lockyer-Palmer: Best Leftover Easter Chocolate Recipes
By Mimikry: Delicious Cured Egg Yolks

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